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Improves voluntary control of upper limbs following stroke and spinal cord injury.
CRANIA brings together research, clinical and academic expertise across multiple disciplines, in an environment with broad access to patients in a World-class Center for Research, Development, Application and Commercialization of Neuromodulation Technologies and Interventions in Toronto.
We are set-up to be fully integrated and first-to-clinic for neuromodulation therapies that can positively impact patients in the next 5 years.
To accelerate the translation of neuromodulation research to patient solutions that improve brain health and function.
The potential of every individual's brain is unlocked for better quality of life.
On behalf of our entire team, we are delighted to welcome you to the Center for Advancing Neurotechnological Innovation to Application (CRANIA). CRANIA brings together research, clinical and academic expertise across multiple disciplines. Our World-Class Center is located in downtown Toronto, in an environment with broad access to patients. Our host institutions and partners are the University Health Network (UHN) and University of Toronto.
Our mission is to accelerate the translation of neuromodulation research to patient solutions that improve brain health and function. We are home to 60+ scientists, and 30+ trainees who are dedicated to improving the lives of our patients and generating new neurotechnology.
At CRANIA, we partner with leading institutions and companies to integrate therapies that positively impact patients' lives. If you would like to work with us, please contact us directly at firstname.lastname@example.org.
We invite you to take a tour of our website and encourage any feedback that will help us understand how we can continue to improve the lives of others.
Dr. Milos R. Popovic and Taufik Valiante
Manufacture electrodes that are fully customizable, biocompatible, collagen-based, with the option of being biodegradable and that minimize magnetic resonance imaging (MRI) artifacts; thus, overcoming limitations of existing electrodes and extending their useful life.
University of Toronto, Mechanical and Industrial Engineering, Faculty of Dentistry
Clean room tools for collagen electrode manufacturing and testing: Electrode surface coating development and testing (Laser Cutter, Maskless writer, High vacuum evaporator) and Collagen electrode development and testing equipment
Develop a next generation implantable device that integrates electrodes from Core A with a wireless monitoring and communication system. Brain activity signals and other inputs will be processed and used, in real time, by the device to stimulate the brain (eg, deliver neuromodulation therapy) in a responsive manner via accurately implanted electrodes.
University of Toronto, Electrical and Computer Engineering Department
Digital components and tools for building circuits and sensors: Wireless Sensor and Stimulator Development, Custom Designed Integrated Circuits, Digital Components, Printed Circuit Board Router, Implantable Sensor Development, Characterization and Validation, Development of Miniaturised Optical Sensors for Diagnostics.
Develop, in collaboration with industry, advanced imaging, electrophysiological measurement and surgical navigation technologies to identify and target specific brain regions associated with disease in grey/white matter with unparalleled accuracy and precision.
Toronto Western Hospital – University Health Network
Low field strength (0.5T) MRI, robotic placement of electrodes, novel registration technologies, surgical\physiological targeting and navigation systems.
Validate technologies from Cores A, B, and C in appropriate animal models. Technologies to be tested include: the wireless communication systems, implantable stimulators, implantable electrodes, connectors, sensors, closed-loop control strategies, coatings and other components of the implantable neuromodulation systems.
Toronto Western Hospital – University Health Network
Animal electrophysiological measurement and stereotaxic surgical systems.
Clinical testing of closed loop algorithms, chips, and stimulation protocols with real time physiological/behavioral/cognitive assessments in healthy individuals and those with neurological conditions (Epilepsy, Parkinsons's etc). Test bed for the development of closed-loop neuromodulation strategies.
Toronto Western Hospital, Toronto Western Hospital Movement Disorders Lab, Toronto Rehabilitation Institute REL (Lyndhurst)
Research EMU amplifier system, Real-time gait analysis, EEG assessment systems, Neurological assessment system, Electrical stimulator, Optical kinematic, CRANIA lab renovations.
Robust HPC infrastructure is required to collect, standardize and perform data analytics. Additionally, the UHN HPC4Health team will work with CRANIA to facilitate the necessary network interconnects to transfer pre-processed data gathered from sensor streams and other sources to HPC4Health. Application of Fujitsu's Digital Annealer to neuromodulation.
University Health Network
Computers and software.
NEUROMODULATION changes brain, spinal cord or nerve function using advanced device(s) that interface with specific areas of the central or peripheral nervous system to reduce symptoms and address underlying disorder(s).
Dr. Alfonso Fasano explains how CRANIA's new gait analysis lab at Toronto Western Hospital uses immersive lab technology to help patients with Parkinson's disease. The project is a product of close collaboration between researchers at the Krembil Brain Institute and the Toronto Rehabilitation Institute.
Staff Scientist & Project Manager
CRANIA Neuromodulation Suite Manager
With new devices, research and innovations, the Krembil Brain Institute has become a leader in the science and practice of neuromodulatory procedures
Pioneering research in neuromodulation at Toronto's University Health Network is improving patients' lives
Imagine: computer chips that are implanted in the brain to prevent memory loss, help stabilize mood and even stop an epileptic seizure. The Center for Advancing Neurological Innovation to Application—CRANIATM—ventures to turn these ideas of science fiction into a reality