Evidence Levels

Level of evidence INESSS-ONF

LEVEL A - Recommendation supported by at least 1 meta-analysis, systematic review, or randomized controlled trial of appropriate size with relevant control group.

LEVEL B - Recommendation supported by cohort studies that at minimum have a comparison group, well-designed single subject experimental designs, or small sample size randomized controlled trials.

LEVEL C - Recommendation supported primarily by expert opinion based on their experience, though uncontrolled case series without comparison groups that support the recommendations are also classified here.