Dr. Krista Lanctôt leads a large interdisciplinary research team whose goal is to optimize treatment for neuropsychiatric symptoms including cognitive changes, apathy, agitation, and mood changes. The research team also focuses on understanding how these neuropsychiatric symptoms may interfere with cardiac rehabilitation. Her research addresses these goals by determining the underlying neurobiology of neuropsychiatric symptoms, examining predictors of treatment response, and using novel or repurposed pharmacological treatments. The research team has also investigated exercise and dietary interventions in the cardiac rehabilitation population. A variety of tools including neuroimaging, lipidomics, serum biomarkers, and neuropsychiatric assessments are used in combination with pharmacotherapeutic trials. This research will contribute to our understanding of the link between neurotransmitter dysfunction, proteins, lipids and metabolites and neuropsychiatric symptoms.